The human memory T cell compartment changes across tissues of the female reproductive tract
| Autor: | Michael F. Fialkow, Valentin Voillet, Jennifer M. Lund, Laura Pattacini, Gretchen M. Lentz, Florian Hladik, Sean M. Hughes, Martin Prlic, Sarah C. Vick, Raphael Gottardo, Anna C Kirby, Amanda S. Woodward Davis |
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| Rok vydání: | 2021 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine T cell Immunology Niche CD8-Positive T-Lymphocytes Biology Article Immunophenotyping Transcriptome Memory T Cells 03 medical and health sciences 0302 clinical medicine T-Lymphocyte Subsets Immunity medicine Humans Immunology and Allergy Compartment (development) Mucous Membrane Lung Gene Expression Profiling CD69 Genitalia Female Phenotype Cell biology 030104 developmental biology medicine.anatomical_structure Organ Specificity Antigens Surface Female Immunologic Memory Biomarkers 030215 immunology |
| Zdroj: | Mucosal immunology |
| ISSN: | 1933-0219 |
| Popis: | Memory CD4 T cells in tissues fulfill numerous functions that are critical for local immune homeostasis and protection against pathogens. Previous studies have highlighted the phenotypic and functional heterogeneity of circulating and tissue-resident memory CD4 T cells across different human tissues such as skin, lung, liver and colon. Comparatively little is known in regard to memory CD4 T cells across tissues of the female reproductive tract (FRT). We examined CD4 T cells in donor-matched vaginal, ecto- and endo-cervical tissues, which differ in mucosal structure and exposure to external environmental stimuli. We hypothesized that this could be reflected by tissue-specific differences in the memory CD4 T cell compartment. We found differences in CD4 subset distribution across these tissues. Specifically, CD69+CD103+ CD4 T cells were significantly more abundant in vaginal than cervical tissues. In contrast, the transcriptional profiles of CD4 subsets were fairly conserved across FRT tissues. CD69+CD103+ CD4 T cells showed a TH17 bias independent of tissue niche. Our data suggest that FRT tissues affect T cell subset distribution but have limited effects on the transcriptome of each subset. We discuss the implications for barrier immunity in the FRT. |
| Databáze: | OpenAIRE |
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