Histopathological maladaptive changes in the explanted human mitral leaflets correlate with changes in echocardiographic leaflet morphology and the severity of ischaemic mitral regurgitation
| Autor: | Nydia Avila-Vanzzini, Patrizio Lancellotti, Luis Alberto Fernandez Calix, Wilman De León López, Enrique Berrios-Bárcenas, Alberto Aranda-Fraustro, Antonio Jordan-Rios, Hector Herrera-Bello, Pedro Rivera-Lara, Jose Antonio Arias-Godínez, Mani A Vannan |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal - Cardiovascular Imaging. 24:392-400 |
| ISSN: | 2047-2412 2047-2404 |
| Popis: | Aims Several changes of the mitral valve (MV) morphology have been previously documented in ischaemic mitral regurgitation (IMR) upon macro and microscopic examination. This study aimed to correlate echocardiographic MV thickening with IMR severity and to delineate the histopathological basis of valve thickening from the explanted leaflets. Methods and results Two hundred and fifty patients were included in the echo-group; of these, 48 patients (19.2%) underwent surgical mitral valve replacement (MVR), including them in the histology-group. By echocardiography, the thickness of the anterior and posterior leaflet was more extensive in moderate to severe IMR, P < 0.001. Histology-group: patients were divided into two groups based on the median thickness: those with cusp thickness Conclusion In ischaemic MR, the thicker the cusps, the worse the MR. Leaflet thickening was due to the myxoid and fibrosis deposition and was detected by echocardiography. Therefore, this method can be helpful in the evaluation of valve remodelling. |
| Databáze: | OpenAIRE |
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