Association of Prenatal Alcohol Exposure and Prenatal Maternal Depression with Offspring Low-Grade Inflammation in Early Adolescence
| Autor: | Oliver Kratz, Gunther H. Moll, Janina Maschke, Anna Eichler, IMAC-Mind-Consortium, Anne-Christine Plank, Tamme W. Goecke, Matthias W. Beckmann, Sophia Bösl, Peter A. Fasching, Jakob Roetner, Nicolas Rohleder, Bernd Lenz, Johannes Kornhuber |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
early adolescence
Male Meconium Longitudinal study medicine.medical_specialty Adolescent Alcohol Drinking Offspring Health Toxicology and Mutagenesis meconium ethyl glucuronide (EtG) low-grade systemic inflammation Systemic inflammation Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ethyl glucuronide Pregnancy Humans Medicine Longitudinal Studies 030212 general & internal medicine Inflammation Depression business.industry Obstetrics Infant Newborn Public Health Environmental and Occupational Health medicine.disease prenatal alcohol exposure (PAE) maternal self-report chemistry Maternal Exposure prenatal depression Prenatal Exposure Delayed Effects Edinburgh Postnatal Depression Scale Biomarker (medicine) Female medicine.symptom business 030217 neurology & neurosurgery high-sensitivity C-reactive protein (hsCRP) |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 18 Issue 15 International Journal of Environmental Research and Public Health, Vol 18, Iss 7920, p 7920 (2021) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph18157920 |
| Popis: | (1) This longitudinal study aimed to investigate the link between prenatal alcohol exposure and prenatal maternal depression with the offspring’s low-grade inflammatory status. (2) Prenatal alcohol exposure was determined via maternal self-report during the 3rd trimester of pregnancy (self-report+: n = 29) and the meconium alcohol metabolite Ethyl Glucuronide (EtG), collected at birth (≥30 ng/g: n = 23). The Edinburgh Postnatal Depression Scale (EPDS) was used to screen for prenatal maternal depressive symptoms during the 3rd trimester (≥10: n = 35). Fifteen years later, 122 adolescents (M = 13.32 years 48.4% female) provided blood samples for the analysis of high sensitivity C-reactive protein (hsCRP M = 0.91 SD = 1.28). (3) Higher hsCRP levels were found in EtG positive adolescents (p = 0.036, ηp2 = 0.04) and an inverse non-significant dose–response relation with hsCRP (r = −0.35, p = 0.113). For maternal self-reported prenatal alcohol consumption (p = 0.780, ηp2 = 0.00) and prenatal depressive symptoms (p = 0.360, ηp2 = 0.01) no differences for hsCRP levels between the affected and unaffected groups were found. (4) Adolescents with prenatal alcohol exposure are at risk for low-grade systemic inflammation. The EtG biomarker may be more accurate compared to self-reports. The findings suggest that prenatal maternal depression does not evoke low-grade systemic inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|