Predictors of lymph-node metastasis in surgically resected T1 colorectal cancer in Western populations
| Autor: | Peng Deng, Fuxin Tang, Hui Li, Ce-Gui Hu, Chenghao Yi, Zhi-Yang Liu, Taicheng Zhou, Zhen Zong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer overall survival medicine.medical_treatment Rectum Lower risk Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Neoadjuvant therapy AcademicSubjects/MED00260 business.industry Hazard ratio end results database Gastroenterology Original Articles medicine.disease Confidence interval medicine.anatomical_structure 030220 oncology & carcinogenesis lymph-node metastasis surveillance T1 colorectal cancer epidemiology 030211 gastroenterology & hepatology business |
| Zdroj: | Gastroenterology Report |
| ISSN: | 2052-0034 |
| DOI: | 10.1093/gastro/goaa095 |
| Popis: | Background The risk of lymph-node metastasis (LNM) in T1 colorectal cancer (CRC) has not been well documented in heterogeneous Western populations. This study investigated the predictors of LNM and the long-term outcomes of patients by analysing T1 CRC surgical specimens and patients’ demographic data. Methods Patients with surgically resected T1 CRC between 2004 and 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with multiple primary cancers, with neoadjuvant therapy, or without a confirmed histopathological diagnosis were excluded. Multivariate logistic-regression analysis was used to identify the predictors of LNM. Results Of the 22,319 patients, 10.6% had a positive lymph-node status based on the final pathology (nodal category: N1 9.6%, N2 1.0%). Younger age, female sex, Asian or African-American ethnicity, poor differentiation, and tumor site outside the rectum were significantly associated with LNM. Subgroup analyses for patients stratified by tumor site suggested that the rate of positive lymph-node status was the lowest in the rectum (hazard ratio: 0.74; 95% confidence interval: 0.63–0.86). Conclusion The risk of LNM was potentially lower in Caucasian patients than in API or African-American patients with surgically resected T1 CRC. Regarding the T1 CRC site, the rectum was associated with a lower risk of LNM. |
| Databáze: | OpenAIRE |
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