Diabetic foot ulcers: Retrospective comparative analysis from Sicily between two eras
| Autor: | Valentina Guarnotta, Stefano Radellini, Enrica Vigneri, Achille Cernigliaro, Felicia Pantò, Salvatore Scondotto, Piero Luigi Almasio, Giovanni Guercio, Carla Giordano |
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| Přispěvatelé: | Guarnotta V, Radellini S, Vigneri E, Cernigliaro A, Pantò F, Scondotto S, Almasio PL, Guercio G, Giordano C. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Comorbidity Antiplatelet Therapy Biochemistry Settore MED/13 - Endocrinologia Endocrinology Medical Conditions Oral Diseases Retrospective Studie Chronic Kidney Disease Medicine and Health Sciences Surgical Amputation Insulin Sicily Ulcers Aged 80 and over Multidisciplinary Pharmaceutics Incidence Middle Aged Diabetic Foot Type 2 Diabetes Hospitalization Nephrology Medicine Female Human Research Article Endocrine Disorders Science Oral Medicine Surgical and Invasive Medical Procedures Signs and Symptoms Life Expectancy Drug Therapy Diabetes Mellitus Renal Diseases Humans Mortality Renal Insufficiency Chronic Aged Retrospective Studies Diabetic Endocrinology Biology and Life Sciences Hormones Diabetes Mellitus Type 2 Metabolic Disorders Clinical Medicine |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 12 (2021) PLoS ONE, Vol 16, Iss 12, p e0259405 (2021) |
| ISSN: | 1932-6203 |
| Popis: | Aim The aim of this study was to analyze changes in the incidence, management and mortality of DFU in Sicilian Type 2 diabetic patients hospitalized between two eras, i.e. 2008–2013 and 2014–2019. Methods We compared the two eras, era1: 2008–13, era2: 2014–19. In era 1, n = 149, and in era 2, n = 181 patients were retrospectively enrolled. Results In the population hospitalized for DFU in 2008–2013, 59.1% of males and 40.9% of females died, whilst in 2014–2019 65.9% of males and 34.1% of females died. Moderate chronic kidney disease (CKD) was significantly higher in patients that had died than in ones that were alive (33% vs. 43%, p < 0.001), just as CKD was severe (14.5% vs. 4%, p < 0.001). Considering all together the risk factors associated with mortality, at Cox regression multivariate analysis only moderate-severe CKD (OR 1.61, 95% CI 1.07–2.42, p 0.021), age of onset greater than 69 years (OR 2.01, 95% CI 1.37–2.95, p Conclusions Patients with DFU have high mortality and reduced life expectancy. Age at onset of diabetic foot ulcer, eGFR values and CKD are the principal risk factors for mortality. |
| Databáze: | OpenAIRE |
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