Orexin-A level elevation in recently abstinent male methamphetamine abusers
| Autor: | Po Yu Chen, Chung-Feng Kao, Wen-Yin Chen, Ming-Chyi Huang, Shih-Ku Lin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine media_common.quotation_subject Amphetamine-Related Disorders Physiology Methamphetamine Young Adult 03 medical and health sciences Orexin-A chemistry.chemical_compound 0302 clinical medicine mental disorders medicine Humans Biological Psychiatry media_common Orexins digestive oral and skin physiology Meth Abstinence Substance Withdrawal Syndrome Orexin Psychiatry and Mental health 030104 developmental biology nervous system chemistry Anesthesia Psychology Biomarkers hormones hormone substitutes and hormone antagonists psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatry Research. 239:9-11 |
| ISSN: | 0165-1781 |
| Popis: | Research has suggested that methamphetamine (METH) use influences orexin regulation. We examined the difference in orexin-A levels between METH abusers and healthy controls. Fasting serum orexin-A levels were measured in 35 participants who used METH in the preceding 3 weeks and 36 healthy controls. We found METH abusers had significantly higher orexin-A levels. No association was observed between orexin-A levels and METH use variables. Our results, consistent with prior preclinical evidence, showed that recent METH exposure is associated with increased orexin-A expression. Further investigation is required to determine whether orexin-A levels normalize after a longer term of abstinence. |
| Databáze: | OpenAIRE |
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