Radiographic vertebral morphology: a diagnostic tool in pediatric osteoporosis
| Autor: | Flavia Henriques, Andrea S. Doria, Sandrine Compeyrot, Earl D. Silverman, Ronald M. Laxer, William G. Cole, Alan Daneman, Outi Mäkitie, Etienne Sochett |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pediatric Osteoporosis Bone density Adolescent Osteoporosis Asymptomatic Absorptiometry Photon Calcitriol Bone Density medicine Humans Child Glucocorticoids Dual-energy X-ray absorptiometry Bone mineral medicine.diagnostic_test business.industry medicine.disease Spine Surgery Vertebra medicine.anatomical_structure Parathyroid Hormone Case-Control Studies Pediatrics Perinatology and Child Health Chronic Disease Regression Analysis Spinal Fractures Calcium Female Secondary osteoporosis Radiology medicine.symptom business |
| Zdroj: | The Journal of pediatrics. 146(3) |
| ISSN: | 0022-3476 |
| Popis: | Objective To assess the value of spinal radiographs in determining the significance of reductions in bone mass or density in chronically ill children. Study design A pediatric scoring method for assessment of osteoporotic vertebral changes, developed on the basis of radiographs of 70 healthy controls and established adult scoring methods, was subsequently used to assess 32 pediatric patients with suspected secondary osteoporosis. Radiographic findings were correlated with bone mineral density (BMD), clinical data, and biochemistry. Results Thirty-two patients (median age 14.1 years) were included. Assessment of spinal radiographs with the developed scoring method found previously undiagnosed spinal compression deformities in 11 patients (34%) of whom 9 were asymptomatic and 8 had lumbar spine (size-corrected) BMD measurements within +/-2.0 SD of the age- and sex-specific norms. Fracture history and cumulative glucocorticoid (GC) dose did not differ between those with and without compression deformities. Conclusions Vertebral compression fractures can be documented in a significant number of chronically ill children and are poorly predicted by single BMD measurements and clinical history. Assessment of vertebral morphology is recommended as an additional tool in the diagnostic workup of pediatric osteoporosis. |
| Databáze: | OpenAIRE |
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