Tailorable Membrane-Penetrating Nanoplatform for Highly Efficient Organelle-Specific Localization
| Autor: | Kajsa Uvdal, Jianxia Jiang, Yuguang Ma, Anna du Rietz, Karin Roberg, Caroline Brommesson, Gang Feng, Xuanjun Zhang, Zhangjun Hu, Xin Zhang, Jiwen Hu, Chunfei Wang, Fengling Zhang, Han-Ming Shen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Annan kemi
Materials science Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanomaterials Biomaterials Organelle General Materials Science Flexibility (engineering) Organelles Fluorescent nanoparticles cell-penetrating cyclic disulfides autophagy bioimaging fluorescent nanoparticles subcellular targeting General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Mitochondria Nanostructures Membrane Nanoparticles 0210 nano-technology Other Chemistry Topics Lysosomes Biotechnology |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany). 17(31) |
| ISSN: | 1613-6829 |
| Popis: | Given the breadth of currently arising opportunities and concerns associated with nanoparticles for biomedical imaging, various types of nanoparticles have been widely exploited, especially for cellular/subcellular level probing. However, most currently reported nanoparticles either have inefficient delivery into cells or lack specificity for intracellular destinations. The absence of well-defined nanoplatforms remains a critical challenge hindering practical nano-based bio-imaging. Herein, the authors elaborate on a tailorable membrane-penetrating nanoplatform as a carrier with encapsulated actives and decorated surfaces to tackle the above-mentioned issues. The tunable contents in such a versatile nanoplatform offer huge flexibility to reach the expected properties and functions. Aggregation-induced emission luminogen (AIEgen) is applied to achieve sought-after photophysical properties, specific targeting moieties are installed to give high affinity towards different desired organelles, and critical grafting of cell-penetrating cyclic disulfides (CPCDs) to promote cellular uptake efficiency without sacrificing the specificity. Hereafter, to validate its practicability, the tailored nano products are successfully applied to track the dynamic correlation between mitochondria and lysosomes during autophagy. The authors believe that the strategy and described materials can facilitate the development of functional nanomaterials for various life science applications. Funding Agencies|STINT Joint China-Sweden Mobility Project [CH2017-7243]; Swedish Research Council (VR)Swedish Research Council [VR 2019-02409, 2020-05437]; China Scholarship Council (CSC)China Scholarship Council; Science and Technology Development Fund, Macau SAR [019/2017/AMJ, 0114/2019/A2]; Carl Tryggers Stiftelse [CTS 19:379]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [Dnr. 5.1-2015-5959]; Centre in Nano Science and technology at LiTH (CeNano); LiU Cancer network at Linkoping University |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text