Human herpesvirus 6 infection mimicking juvenile myelomonocytic leukemia in an infant
| Autor: | Adonis Lorenzana, Hadi Sawaf, Peter D. Emanuel, Hernando Lyons, Martha Higgins, Donald Carrigan |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Virus Cultivation Herpesvirus 6 Human Hepatosplenomegaly Roseolovirus Infections Bone Marrow Cells medicine.disease_cause Polymerase Chain Reaction Herpesviridae Leukemia Myelomonocytic Acute Colony-Forming Units Assay Diagnosis Differential Bone Marrow medicine Humans Cells Cultured biology Juvenile myelomonocytic leukemia business.industry Viral culture Infant Newborn Granulocyte-Macrophage Colony-Stimulating Factor Acute Kidney Injury biology.organism_classification medicine.disease Jaundice Neonatal Leukemia medicine.anatomical_structure Immunology DNA Viral Human herpesvirus 6 Viral disease Bone marrow medicine.symptom business |
| Zdroj: | Journal of pediatric hematology/oncology. 24(2) |
| ISSN: | 1077-4114 |
| Popis: | In vitro cell culture studies of bone marrow and peripheral blood progenitor cells from patients with juvenile myclomonocytic leukemia (JMML) consistently show spontaneous proliferation and selective hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). This GM-CSF hypersensitivity dose-response assay has become a component of the international diagnostic criteria for JMML. The authors report a 2-week-old boy with perinatal human herpesvirus 6 (HHV-6) infection in whom in vitro bone marrow culture studies suggested the diagnosis of JMML by showing increased spontaneous proliferation, inhibition of this growth by anti-GM-CSF antibodies, and hypersensitivity to GM-CSF. Polymerase chain reaction viral studies from whole blood DNA and the shell vial viral culture assay were both positive for HHV-6. The patient's condition improved with expectant treatment, with an eventual return to normal blood counts and resolution of hepatosplenomegaly. This case of perinatal HHV-6 infection shows that viruses can initially mimic the in vitro culture results found in patients with JMML. It also illustrates that patients suspected of having JMML should be observed if there are no signs of progressive disease and concurrent features suggestive of viral infection. |
| Databáze: | OpenAIRE |
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