Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis
| Autor: | Maxime Gauberti, Fabian Docagne, Richard Macrez, Antoine P. Fournier, Aurélien Quenault, Denis Vivien |
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| Rok vydání: | 2018 |
| Předmět: |
Indocyanine Green
Pathology medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Contrast Media Cisterna magna Mice 03 medical and health sciences Meglumine 0302 clinical medicine Cisterna Magna Organometallic Compounds medicine Animals Pathophysiology of multiple sclerosis Parenchymal Tissue Neuroinflammation Cerebrospinal Fluid business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis Brain medicine.disease Spinal cord Magnetic Resonance Imaging medicine.anatomical_structure Spinal Cord Neurology Cerebrospinal fluid circulation Original Article Female Glymphatic system Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | J Cereb Blood Flow Metab |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x18754732 |
| Popis: | An alteration of parenchymal cerebrospinal fluid circulation (CSF) has been proposed to take part in the pathophysiology of multiple sclerosis. By using an intragate T1-weighted high-resolution MRI of the spinal cord of freely breathing mice injected with a gadolinium chelate in the cisterna magna, we show that a parenchymal CSF circulation exists in the spinal cord, in addition to that originally described in the brain. In experimental autoimmune encephalomyelitis, a model of multiple sclerosis, we show a reduction of parenchymal CSF circulation specifically in the spinal cord but not in the brain. |
| Databáze: | OpenAIRE |
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