Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology
| Autor: | Poonam Bhadja, Shi-Hai Xu, Jignesh Lunagariya, Rohit L. Vekariya, Shenghui Zhong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Marine conservation
Indoles Stereochemistry Anti-Inflammatory Agents Antineoplastic Agents Red algae Chemistry Techniques Synthetic Indole Alkaloids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adjuvants Immunologic Anti-Infective Agents Drug Discovery Botany Animals Caulerpa Humans Hypoglycemic Agents Bis indole 030304 developmental biology Pharmacology 0303 health sciences Natural product biology Alkaloid Total synthesis General Medicine biology.organism_classification chemistry 030220 oncology & carcinogenesis Rhodophyta Green algae |
| Zdroj: | Mini reviews in medicinal chemistry. 19(9) |
| ISSN: | 1875-5607 |
| Popis: | Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin which has been isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, was tested for several therapeutic potentials such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti- larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activities as well as a means of other chemical agents. Herein, we summarized the discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin and its functional analogues have also been reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|