Low doses of atropine sulfate impair retention of a well-learned spatial task
| Autor: | L. Gallego, D. I. Welch, T. M. Rauch |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Atropine
Male medicine.medical_treatment Spatial Behavior Escape latency Memory Reaction Time Atropine sulfate medicine Animals Dose effect Saline Biological Psychiatry Cholinesterase Dose-Response Relationship Drug biology Chemistry General Neuroscience Low dose Retention Psychology Rats Psychiatry and Mental health Neurology Anesthesia biology.protein Neurology (clinical) After treatment medicine.drug |
| Zdroj: | Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 1:219-228 |
| ISSN: | 1435-1463 0936-3076 |
| DOI: | 10.1007/bf02248671 |
| Popis: | Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40, and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10 mg/kg, iv) than have previously been shown to disrupt spatial retention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink