Formaldehyde Exposure and Epigenetic Effects: A Systematic Review

Autor: Ivo Iavicoli, Francesco Flaviano Russo, Veruscka Leso, Maria Carmela Macrini
Přispěvatelé: Leso, V., Macrini, M. C., Russo, F., Iavicoli, I.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.disease_cause
Bioinformatics
lcsh:Technology
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
microRNA
medicine
General Materials Science
Epigenetics
Instrumentation
lcsh:QH301-705.5
Carcinogen
Risk assessment
Fluid Flow and Transfer Processes
DNA methylation
biology
histone modifications
lcsh:T
Process Chemistry and Technology
General Engineering
MicroRNA
Methylation
occupational exposure
lcsh:QC1-999
Computer Science Applications
Olfactory bulb
microRNAs
Biological monitoring
030104 developmental biology
Histone
Risk management
lcsh:Biology (General)
lcsh:QD1-999
lcsh:TA1-2040
030220 oncology & carcinogenesis
biology.protein
formaldehyde
Histone modification
lcsh:Engineering (General). Civil engineering (General)
Genotoxicity
epigenetic
lcsh:Physics
Zdroj: Applied Sciences, Vol 10, Iss 2319, p 2319 (2020)
ISSN: 2076-3417
Popis: Formaldehyde (FA) is a general living and occupational pollutant, classified as carcinogenic for humans. Although genotoxicity is recognized as a FA mechanism of action, a potential contribution of epigenetic effects cannot be excluded. Therefore, aim of this review is to comprehensively assess possible epigenetic alterations induced by FA exposure in humans, animals, and cellular models. A systematic review of Pubmed, Scopus, and Isi Web of Science databases was performed. DNA global methylation changes were demonstrated in workers exposed to FA, and also in human bronchial cells. Histone alterations, i.e., the reduction in acetylation of histone lysine residues, in human lung cells were induced by FA. Moreover, a dysregulation of microRNA expression in human lung adenocarcinoma cells as well as in the nose, olfactory bulb and white blood cells of rodents and nonhuman primates was reported. Although preliminary, these findings suggest the role of epigenetic modifications as possible FA mechanisms of action that need deeper qualitative and quantitative investigation. This may allow to define the role of such alterations as indicators of early biological effect and the opportunity to include such information in future risk assessment and management strategies for public and occupationally FA-exposed populations.
Databáze: OpenAIRE
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