Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
| Autor: | Anna Vašků, Jan Máchal, Zbyněk Šplíchal, Filip Zlámal, Pavel Ventruba, Zuzana Hodická, Tereza Pavlová, Jolana Lipková, Julie Bienertová-Vašků |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Fetal Membranes Premature Rupture medicine.medical_specialty Term Birth Adipokine Enzyme-Linked Immunosorbent Assay GPI-Linked Proteins Statistics Nonparametric Cohort Studies 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Lectins Internal medicine Genotype medicine Humans Genetic variability Allele Polymorphism Genetic 030219 obstetrics & reproductive medicine Obstetrics business.industry Infant Newborn Obstetrics and Gynecology Preterm Births medicine.disease 3. Good health 030104 developmental biology Endocrinology Pediatrics Perinatology and Child Health Cytokines Premature Birth Female business Premature rupture of membranes |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 31:1689-1695 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself. |
| Databáze: | OpenAIRE |
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