Renal function in predialysis children with chronic renal failure treated with erythropoietin
| Autor: | Rafael T. Krmar, Bernd Klare, Elke Wühl, Karl Schärer, Norbert Gretz |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Adolescent Anemia Urology Renal function Blood Pressure Kidney Function Tests Hemoglobins chemistry.chemical_compound Renal Dialysis Internal medicine medicine Humans Child Erythropoietin Retrospective Studies Creatinine Maintenance dose business.industry Infant medicine.disease Recombinant Proteins Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health Kidney Failure Chronic Female Hemoglobin business Kidney disease medicine.drug |
| Zdroj: | Pediatric Nephrology. 11:69-73 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s004670050234 |
| Popis: | To assess the effect of long-term administration of human recombinant erythropoietin (EPO) on renal function, 11 anemic children aged 1.4-17.2 years were followed for 10-61 (mean 31) months on treatment. During EPO therapy the mean hemoglobin rose from 8.1 to 11.1 g/dl at the last observation. The final maintenance dose ranged between 70 and 300 U/kg per week. The rate of deterioration of renal function was calculated by comparing the slope of the regression lines of reciprocal serum creatinine values (SCr) derived from a mean of 20 values per patient obtained over 8-50 (mean 29) months before and a mean of 24 SCR values during EPO therapy. The individual slopes improved after initiation of EPO therapy in all but 3 patients, but the mean change of slope (from -0.0521 to -0.0299) was not significant. The study suggests that in most children with predialysis chronic renal failure long-term administration of EPO is not associated with accelerated deterioration but rather with delayed deterioration of renal function. |
| Databáze: | OpenAIRE |
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