Relationship between cortisol, life events and metabolic syndrome in men
| Autor: | Yori Gidron, Halina Grosman, Laura Schreier, Bibiana Fabre, Gabriela Berg, Carlos Nolazco, Viviana Mesch, Osvaldo Mazza, Nahuel Fernandez Machulsky |
|---|---|
| Přispěvatelé: | Basic (bio-) Medical Sciences, Neuroprotection & Neuromodulation |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Physiology Blood Pressure Overweight Body Mass Index Life Change Events Behavioral Neuroscience Internal medicine medicine Humans Chronic stress Triglycerides Abdominal obesity Aged Metabolic Syndrome Marital Status Endocrine and Autonomic Systems Metabolic Syndrome X Cholesterol HDL Smoking Middle Aged medicine.disease Lipoproteins LDL Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology Blood pressure Socioeconomic Factors Relative risk Educational Status Regression Analysis Waist Circumference medicine.symptom Metabolic syndrome Psychology Body mass index medicine.drug |
| Zdroj: | Stress. 16:16-23 |
| ISSN: | 1607-8888 1025-3890 |
| DOI: | 10.3109/10253890.2012.676112 |
| Popis: | Psychological factors and stressful life events (LE) are considered to play a role in the onset of the metabolic syndrome (MS). We tested the association between LE and cortisol, a marker of chronic stress, with the risk of developing MS and their interaction. From a total number of 2906 men who completed a screening for the early detection of prostate cancer, 149 healthy men (mean ± SD age, 58.6 ± 7.7 years) were included in this study. Participants were assessed by the Holmes and Rahe questionnaire about their experience of LE during the previous 1-5 years. MS was diagnosed according to National Cholesterol Education Program-Adult Treatment Panel III (ATP-III) and International Diabetes Federation (IDF) criteria. Serum cortisol was measured at 08:00-09:00 h. Participants with MS (IDF criteria) reported significantly more past LE (p = 0.009) and greater summed weight of LE (p = 0.049) than those without MS. Furthermore, LE interacted with cortisol in relation to MS: in men with increased serum cortisol levels ( ≥ 13.7 μg/dl), number of LE significantly predicted MS-status (relative risk (RR) = 1.16, p = 0.03), whereas in men with low cortisol, LE were unrelated to MS (p = 0.52). We conclude that LE were significantly more prevalent in men with the MS than without the MS, according to IDF criteria, independent of the effects of age and body mass index, especially in men with increased serum cortisol levels. |
| Databáze: | OpenAIRE |
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