Role of type I interferon receptor signaling on NK cell development and functions
| Autor: | S. M. Shahjahan Miah, Cindy Banh, Zachary S. Wilson, Laurent Brossay, Jean Guan, Timothy K. Erick |
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| Rok vydání: | 2014 |
| Předmět: |
Adoptive cell transfer
Cell signaling Muromegalovirus Cell Immunology lcsh:Medicine Context (language use) Bone Marrow Cells Receptor Interferon alpha-beta Cell Maturation Interferon-gamma Mice medicine Medicine and Health Sciences Animals Humans lcsh:Science Multidisciplinary biology Cell growth lcsh:R Gene Expression Regulation Developmental Biology and Life Sciences Adoptive Transfer Immunity Innate 3. Good health Cell biology Killer Cells Natural medicine.anatomical_structure Infectious Diseases Integrin alpha M Liver Organ Specificity biology.protein lcsh:Q Bone marrow Signal Transduction Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 10, p e111302 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Type I interferons (IFN) are unique cytokines transcribed from intronless genes. They have been extensively studied because of their anti-viral functions. The anti-viral effects of type I IFN are mediated in part by natural killer (NK) cells. However, the exact contribution of type I IFN on NK cell development, maturation and activation has been somewhat difficult to assess. In this study, we used a variety of approaches to define the consequences of the lack of type I interferon receptor (IFNAR) signaling on NK cells. Using IFNAR deficient mice, we found that type I IFN affect NK cell development at the pre-pro NK stage. We also found that systemic absence of IFNAR signaling impacts NK cell maturation with a significant increase in the CD27+CD11b+ double positive (DP) compartment in all organs. However, there is tissue specificity, and only in liver and bone marrow is the maturation defect strictly dependent on cell intrinsic IFNAR signaling. Finally, using adoptive transfer and mixed bone marrow approaches, we also show that cell intrinsic IFNAR signaling is not required for NK cell IFN-γ production in the context of MCMV infection. Taken together, our studies provide novel insights on how type I IFN receptor signaling regulates NK cell development and functions. |
| Databáze: | OpenAIRE |
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