Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase
| Autor: | Jalal Uddin, Abrar Hussain, Saeed Khan, Arif Ullah Khan, Ahmed Al-Harrasi, Sagheer Ahmed, Ajmal Khan, Sidrah Tariq Khan, Muhammad Kazim Zargaham |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Taue protein RM1-950 Pharmacology Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alzheimer Disease Galantamine medicine Animals Humans Dementia Glutamate receptor antagonist Donepezil Rivastigmine Biological Products business.industry Memantine General Medicine medicine.disease Acetylcholinesterase Acetylcholinesterase inhibitors 030104 developmental biology chemistry 030220 oncology & carcinogenesis Tacrine Amyloid β-peptide Cholinesterase Inhibitors Therapeutics. Pharmacology business Alzheimer’s disease medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111609-(2021) |
| ISSN: | 0753-3322 |
| Popis: | Alzheimer's disease (AD), is the most common type of dementia primarily affecting the later years of life. Its prevalence is likely to increase in any aging population and will be a major burden on healthcare system by the mid of the century. Despite scientific and technological breakthroughs in the last 50 years, that have expanded our understanding of the disease on a system, cellular and molecular level, therapies that could stop or slow the progression of the disease are still unavailable. The Food and Drug Administration (FDA), has approved acetylcholinesterase (AChE) inhibitors (donepezil, galantamine, tacrine and rivastigmine) and glutamate receptor antagonist (memantine) for the treatment of AD. In this review we summarize the studies reporting phytocompounds and extracts from medicinal plants that show AChE inhibitory activities and could be of potential benefit in AD. Future research directions are suggested and recommendations made to expand the use of medicinal plants and their formulations to prevent, mitigate and treat AD. |
| Databáze: | OpenAIRE |
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