Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator
| Autor: | Takayuki Doi, Hidenori Watanabe, Miho Izumikawa, Kazuo Shin-ya, Yukiko Umeda, Shohei Sakuda, Ken Ishigami, Hiromichi Nagasawa, Yoichi Nakao, Motoki Takagi, Kazuo Furihata |
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| Rok vydání: | 2007 |
| Předmět: |
Streptomyces violaceoniger
Molecular Structure Chemistry Stereochemistry Organic Chemistry Regulator Stereoisomerism Biochemistry Peptides Cyclic Streptomyces Absolute structure chemistry.chemical_compound Glucose Neoantimycin Tumor Cells Cultured Humans Molecular chaperone GRP78 Macrolides Physical and Theoretical Chemistry Organic Chemicals Endoplasmic Reticulum Chaperone BiP Derivative (chemistry) Heat-Shock Proteins Molecular Chaperones |
| Zdroj: | Organic letters. 9(21) |
| ISSN: | 1523-7060 |
| Popis: | In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A. |
| Databáze: | OpenAIRE |
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