Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration

Autor: Lourdes Recha-Sancho, Soledad Pérez-Amodio, Miguel A. Mateos-Timoneda, Gerard Rubí-Sans, Carlos E. Semino, Elisabeth Engel
Přispěvatelé: Universitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica, Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Cartilage
Articular
lcsh:QR1-502
Articular cartilage
02 engineering and technology
Regenerative Medicine
Biochemistry
lcsh:Microbiology
Articular cartilage repair
chondrogenic differentiation
Cells
Cultured
Three-dimensional printing
0303 health sciences
3d printing
Cell Differentiation
3D printing
021001 nanoscience & nanotechnology
3. Good health
Cell biology
Polycaprolactone
medicine.anatomical_structure
Enginyeria de teixits
Printing
Three-Dimensional
Enginyeria biomèdica
0210 nano-technology
Biomedical engineering
Impressió 3D
Cartílags
3d printed
Enginyeria dels materials [Àrees temàtiques de la UPC]
Article
03 medical and health sciences
polycaprolactone
medicine
Humans
Regeneration
Severe pain
Tissue engineering
Molecular Biology
Cell Proliferation
030304 developmental biology
RAD16-I self-assembling peptide
Tissue Engineering
Chondrogenic differentiation
business.industry
Cartilage
Regeneration (biology)
Mesenchymal stem cell
Mesenchymal Stem Cells
Chondrogenesis
rad16-i self-assembling peptide
business
Zdroj: Biomolecules, Vol 10, Iss 1, p 52 (2019)
Biomolecules
Volume 10
Issue 1
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Popis: Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe pain, loss of mobility and consequently, a loss of quality of life. Current strategies in medicine are focused on the partial or total replacement of affected joints, physiotherapy and analgesics that do not address the underlying pathology. In an attempt to find an alternative therapy to restore or repair articular cartilage functions, the use of bioengineered tissues is proposed. In this study we present a three-dimensional (3D) bioengineered platform combining a 3D printed polycaprolactone (PCL) macrostructure with RAD16-I, a soft nanofibrous self-assembling peptide, as a suitable microenvironment for human mesenchymal stem cells&rsquo
(hMSC) proliferation and differentiation into chondrocytes. This 3D bioengineered platform allows for long-term hMSC culture resulting in chondrogenic differentiation and has mechanical properties resembling native articular cartilage. These promising results suggest that this approach could be potentially used in articular cartilage repair and regeneration.
Databáze: OpenAIRE
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