pH-Responsive Lignin-Based Nanomicelles for Oral Drug Delivery
| Autor: | Yanan Yin, Jienan Chen, Peng Zhan, Zhiping Wu, Weihua Luo, Xinyi Liu, Cheng Lianghao, Lin Zhang, Shibo Liu, Bin Deng, Nie Shaofei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Stromal cell Biocompatibility Ibuprofen 01 natural sciences Micelle Lignin Cell Line Gel permeation chromatography Mice Drug Delivery Systems Amphiphile Animals Humans Fourier transform infrared spectroscopy Particle Size Micelles Drug Carriers Chemistry 010401 analytical chemistry General Chemistry Hydrogen-Ion Concentration In vitro 0104 chemical sciences Drug Liberation Cell culture Biophysics General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Journal of agricultural and food chemistry. 68(18) |
| ISSN: | 1520-5118 |
| Popis: | A pH-stimuli amphiphilic lignin-based copolymer was prepared, and it could self-assemble to form spherical nanomicelles with the addition of "switching" water. The morphology, structure, and physical properties of micelles were characterized with transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), particle-size analysis, and zeta-potential measurement. In vitro drug release exemplified that the micelles were pH-sensitive, retaining more than 84.36% ibuprofen (IBU) in simulated gastric fluid (pH 1.5) and presenting a smooth release of 81.81% IBU in simulated intestinal fluid (pH 7.4) within 72 h. Cell culture studies showed that the nanomicelles were biocompatible and boosted the proliferation of human bone marrow stromal cells hBMSC and mouse embryonic fibroblast cells NIH-3T3. Interestingly, the nanomicelles inhibited the survival of human colon cancer cells HT-29 with a final survival rate of only 5.34%. Therefore, this work suggests a novel strategy to synthesize intelligent lignin-based nanomicelles that show a great potential as oral drug carriers. |
| Databáze: | OpenAIRE |
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