NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis
| Autor: | Taotao Ma, Jun Li, Yao Yao, Xing Yan, Yaru Liu, Xiao-Feng Li, Hai-xia Yu, Cheng Huang, Ruo-nan Chen, Jie-quan Wang, Qingqing Xu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Freund's Adjuvant Proinflammatory cytokine Pathogenesis Arthritis Rheumatoid Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine NLRC5 medicine Animals Molecular Biology Cell Proliferation business.industry Synovial Membrane Intracellular Signaling Peptides and Proteins NF-kappa B NFKB1 Rats 030104 developmental biology medicine.anatomical_structure Cytokine Gene Expression Regulation Freund's adjuvant 030220 oncology & carcinogenesis Cancer research Cytokines Female Synovial membrane Signal transduction business Signal Transduction |
| Zdroj: | Molecular immunology. 91 |
| ISSN: | 1872-9142 |
| Popis: | Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and the pathogenesis remains unclear. Previous studies suggested that fibroblast-like synoviocytes (FLSs) play an important role in RA pathogenesis, including the injury of cartilage, the hyperplasia of the synovium and the release of inflammatory cytokines. We used complete Freund’s adjuvant (CFA) induced rats as animal models for studying the RA pathogenesis. NLRC5 as the largest member of the NLR family has been reported to play a critical role in regulating immune responses. Increasing evidence suggests that NLRC5 is an pivotal negative modulator of inflammatory pathways. We investigated the mechanisms and signaling pathways of NLRC5 in RA progression. Significantly increased expression of NLRC5 was found in AA rats synovial tissues and cells. And high expression of inflammatory cytokine and cell proliferation of FLSs accompanied with NLRC5 overexpression, but inhibited in cells with NLRC5 silencing treatment. Interestingly, we found that overexpression of NLRC5 also coordinated the activation of NF-κB signaling pathway. These results suggested that NLRC5 promotes RA progression via the NF-κB signaling pathway potentially. |
| Databáze: | OpenAIRE |
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