Effect of Ventriculo-Cisternal Perfusion with Angiotensin II and Indomethacin on the Plasma Vasopressin Concentration
| Autor: | M. Yamamoto, R. E. Shade, Leonard Share |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Time Factors Vasopressins Endocrinology Diabetes and Metabolism Indomethacin Blood Pressure Cerebral Ventricles Plasma Cellular and Molecular Neuroscience Dogs Endocrinology Internal medicine Cisterna Magna Renin Renin–angiotensin system medicine Animals Ventriculo cisternal perfusion Angiotensin II receptor type 1 Endocrine and Autonomic Systems Chemistry Angiotensin II Prostaglandins E Osmolar Concentration Perfusion Prostaglandin biosynthesis Cerebral ventricle Drug Antagonism hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroendocrinology. 25:166-173 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000122738 |
| Popis: | In anesthetized dogs, perfusion of the cerebral ventricles with indomethacin (IM), an inhibitor of prostaglandin biosynthesis, at rates of 1.9 or 7.6 microgram/min was without effect on the plasma ADH concentration. Ventriculo-cisternal perfusion with angiotensin II (AII; 19 ng/min) resulted in a 3-fold increase in the plasma ADH concentration within 45 min. When AII and IM were perfused together, the plasma ADH concentration increased only 2-fold, a response which was significantly lower than that obtained with AII alone. Thus, the ability of central AII to stimulate ADH release may depend, at least in part, upon the local release of prostaglandins. |
| Databáze: | OpenAIRE |
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