Cord blood mononuclear cell responsiveness to beta-lactoglobulin: T-cell activity in 'atopy-prone' and 'non-atopy-prone' newborns
| Autor: | Achille Stabile, Marco Piastra, Giuseppina Fioravanti, Giovanni Pani, Massimo Castagnola, Francesco Ria |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cellular immunity
Allergy Ovalbumin T-Lymphocytes Immunology Population Milk allergy Lactoglobulins Biology medicine.disease_cause Lymphocyte Activation Atopy Epitopes Allergen Antigen Risk Factors medicine Immunology and Allergy Humans education education.field_of_study Infant Newborn food and beverages General Medicine HLA-DR Antigens medicine.disease Fetal Blood biology.protein Interleukin-4 Milk Hypersensitivity |
| Zdroj: | International archives of allergy and immunology. 104(4) |
| ISSN: | 1018-2438 |
| Popis: | We have studied the T-cell-mediated response to the major allergen of cow's milk, in a group of newborns at risk of developing cow's milk allergy, and in a control group. Before any atopic status has developed, we observe beta-lactoglobulin-specific primary proliferation only in the group at risk for food-related allergies. In this group, the capability to proliferate is not due to placental transmission of 'factors' from allergic mothers. The recognition of the tested beta-lactoglobulin peptides does not show major differences between the responder and nonresponder populations. In the responder population, the response to p145-161 appears linked to a primary response to ovalbumin, another frequent food allergen. On the basis of our findings, we propose a model in which development of allergic diseases is linked to an alteration of T-cell activation through the engagement by the antigen; the HLA phenotype determines the allergen(s) involved, and other genetic or environmental factors dictate the clinical characteristics of the disease. |
| Databáze: | OpenAIRE |
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