Targeting and retention of Golgi membrane proteins
| Autor: | Carolyn E. Machamer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Signal peptide
ST—α2 6-sialyltransferase DPAP A—dipeptidyl aminopeptidase A Golgi Apparatus Biology medicine.disease_cause Article GnTI—N-acetylglucosaminyltransferase I symbols.namesake Structure-Activity Relationship Organelle Protein targeting medicine Humans TGN—traps-Golgi network GT—β1 4-galactosyltransferase IBV—infectious bronchitis virus Golgi membrane Membrane Proteins Biological Transport Cell Biology Golgi apparatus TMD—transmembrane domain Cell biology Transmembrane domain CGN—cis-Golgi network Membrane protein Biochemistry Cytoplasm symbols ER-endoplasmic reticulum Signal Transduction |
| Zdroj: | Current Opinion in Cell Biology |
| ISSN: | 1879-0410 0955-0674 |
| Popis: | Recent cloning of genes encoding membrane proteins of the Golgi complex has allowed investigation of protein targeting to this organelle. Targeting signals have been identified in three glycosyltransferases, a viral envelope protein and several proteins of the trans-Golgi network. Interestingly, the targeting signals for membrane proteins of the Golgi stacks seem to be contained in transmembrane domains. Information in the cytoplasmic tails is required for the targeting of trans-Golgi network proteins. Mechanisms involving both retention and retrieval have been invoked. |
| Databáze: | OpenAIRE |
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