Comparison of clinical and serological features of RT-PCR positive and negative COVID-19 patients
Autor: | Jun Liu, Xiaoli Tian, Caiqin Li, Qi Su, Weidong Li, Yuting Li, Lei Chen |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male 2019-20 coronavirus outbreak Medicine (General) Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Clinical manifestation 030204 cardiovascular system & hematology Biochemistry Serology 03 medical and health sciences coronavirus disease 2019 0302 clinical medicine R5-920 antibody Medicine Severe acute respiratory syndrome coronavirus 2 Humans 030212 general & internal medicine Retrospective Studies business.industry Reverse Transcriptase Polymerase Chain Reaction Biochemistry (medical) clinical manifestation Outbreak COVID-19 Retrospective cohort study Cell Biology General Medicine Middle Aged Virology serological test Real-time polymerase chain reaction Female business Retrospective Clinical Research Report |
Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 49 (2021) |
ISSN: | 1473-2300 0300-0605 |
Popis: | Background In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan, China, and led to a global epidemic. We aimed to compare the clinical and serological features of COVID-19 patients with positive and negative reverse transcriptase polymerase chain reaction (RT-PCR) tests. Methods This was a retrospective cohort study conducted from 9 February to 4 April 2020. COVID-19 patients at Leishenshan Hospital in Wuhan, China (125 total cases; 87 RT-PCR positive and 38 RT-PCR negative) were included. COVID-19 serology was assessed by colloidal gold assay. All cases were analyzed for demographic, clinical, and serological features. Results There were no significant differences in most demographic features, clinical symptoms, complications or treatments of RT-PCR positive and negative COVID-19 patients. Serum IgM/IgG was positive in 82 (94%) and 33 (87%) RT-PCR positive and negative cases, respectively. IgM was detectable as early as 3 days after symptom onset and was undetectable 60 days after symptom onset. By contrast, IgG could be detected only 10 days after symptom onset and reached its peak 60 days after symptom onset. Conclusions Serological tests performed during the appropriate time window of disease progression could be valuable auxiliary methods to RT-PCR in COVID-19 patients. |
Databáze: | OpenAIRE |
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