Aluminum disrupts the prenatal development of the male and female gerbil prostate (Meriones unguiculatus)
| Autor: | Sebastião Roberto Taboga, Mônica S. Campos, Fernanda C. A. Santos, Manoel F. Biancardi, Janaína R. Costa, Liana da Silva Gomes, Mara Rubia Marques, Paulo César Ghedini |
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| Přispěvatelé: | Universidade Federal de Goiás (UFG), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antiandrogens Male Proliferation index Female prostate Clinical Biochemistry Physiology Biology Endocrine Disruptors Gerbil Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Prostate Pregnancy medicine Aluminum Chloride Animals Increased serum testosterone level Ventral prostate Molecular Biology Metalloestrogen Anogenital distance Prenatal development Androgen receptor 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Prenatal Exposure Delayed Effects Estrogen receptor alpha Female Gerbillinae Hormone |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1096-0945 |
| Popis: | Made available in DSpace on 2019-10-06T16:15:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de Goiás Normal prostate development is highly dependent of an equilibrated hormonal regulation, so that sensible interferences during this period may predispose the gland to lesions during aging. Industrial activities have increased the exposure of this gland to active elements found in environment, such as aluminum (Al). Al presents toxic effect for living beings, having the potential to disrupt the development and growth of several organs and systems. Therefore, the aim of this study was to evaluate whether the prenatal exposure to Al may alter the development and morphophysiology of the gerbil prostate (Meriones unguiculatus). Pregnant females were orally exposed to aluminum chloride (100 mg/kg/day) from 17th to 21th gestational day. Following the birth, the male and female pups were euthanized with 1 (PN1) and 90-days-old (PN90). The prostates were collected for biometrical, three-dimensional reconstruction, morphometrical, stereological, and immunohistochemical analysis. Results indicated that Al decreases the body weight of PN1 males and females, and also reduce the anogenital distance of PN1 females. Moreover, Al changed the prostate developmental patterns of PN1 animals, causing an increase in proliferative status and decreasing androgen receptor immunostaining. The results suggest that Al-promoted changes were permanent, since low androgen receptor frequency, increased serum testosterone levels and high proliferation index were observed in adult gerbils. This study demonstrated that body and prostatic changes were more pronounced in females than in males, and that Al performed as an endocrine-disrupting chemical in gerbils. Department of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of Goiás, Goiânia Department of Biology Laboratory of Microscopy and Microanalysis University Estadual Paulista – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto Department of Pharmacology Laboratory of Molecular and Biochemistry Pharmacology Institute of Biological Sciences Federal University of Goiás, Goiânia Department of Biology Laboratory of Microscopy and Microanalysis University Estadual Paulista – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto Fundação de Amparo à Pesquisa do Estado de Goiás: 08/2018 |
| Databáze: | OpenAIRE |
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