Role of pyroptosis in diabetic retinopathy and its therapeutic implications
| Autor: | Ilma Monalisa, Muhammad Zaeem, Fahad Munir, Abdullah Al Mamun, Jian Xiao, Anjuman Ara Mimi, Afroza Akter, Yanqing Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death Inflammasomes Caspase 1 Pathogenesis 03 medical and health sciences 0302 clinical medicine NLR Family Pyrin Domain-Containing 3 Protein Pyroptosis medicine Animals Humans Secretion Pharmacology Diabetic Retinopathy business.industry Intracellular Signaling Peptides and Proteins Gasdermin D Inflammasome Diabetic retinopathy Phosphate-Binding Proteins medicine.disease 030104 developmental biology business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Pharmacology. 904:174166 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2021.174166 |
| Popis: | Pyroptosis has recently been established as a term of programmed-inflammatory cell death. Pyroptosis is mainly divided into two molecular signaling pathways, including caspase-1-dependent canonical and caspase-4/5/11-dependent non-canonical inflammasome pathways. Extensive investigations have reported inflammasome activation facilitates the maturation and secretion of the inflammatory factors interleukin-1β/18 (IL-1β/18), cleavage of gasdermin D (GSDMD), and leading to the stimulation of pyroptosis-mediated cell death. Furthermore, accumulating studies report NLRP3 inflammasome activation plays a significant role in triggering the pyroptosis-mediated cell death and promotes the pathogenesis of diabetic retinopathy (DR). Our current review elaborates on the molecular mechanisms of pyroptosis-signaling pathways and their potential roles in the pathogenesis and impact of DR development. We also emphasize several investigational molecules regulating key steps in pyroptotic-cell death to create new comprehensions and findings to explore the pathogenesis of DR advancement. Our narrative review concisely suggests these potential pharmacological agents could be promising therapies to treat and manage DR in the future. |
| Databáze: | OpenAIRE |
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