Impacts of glycemic variability on the relationship between glucose management indicator from iPro™2 and laboratory hemoglobin A1c in adult patients with type 1 diabetes mellitus
| Autor: | Xueying Zheng, Hua Liang, Yongwen Zhou, Daizhi Yang, Bin Yao, Jianping Weng, Jinhua Yan, Hongrong Deng, Liling Qiu, Jing Lv, Hongxia Liu, Fang Liu, Wen Xu, Sihui Luo, Funeng Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Type 1 diabetes lcsh:RC648-665 endocrine system diseases Glycated hemoglobin-A1c Adult patients business.industry Endocrinology Diabetes and Metabolism nutritional and metabolic diseases medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology Glucose management Internal medicine Diabetes mellitus Medicine Hemoglobin business Glycemic |
| Zdroj: | Therapeutic Advances in Endocrinology and Metabolism, Vol 11 (2020) |
| ISSN: | 2042-0196 2042-0188 |
| Popis: | Aims: Our aim was to investigate the impact of glycemic variability (GV) on the relationship between glucose management indicator (GMI) and laboratory glycated hemoglobin A1c (HbA1c). Methods: Adult patients with type 1 diabetes mellitus (T1D) were enrolled from five hospitals in China. All subjects wore the iPro™2 system for 14 days before HbA1c was measured at baseline, 3 months and 6 months. Data derived from iPro™2 sensor was used to calculate GMI and GV parameters [standard deviation (SD), glucose coefficient of variation (CV), and mean amplitude of glycemic excursions (MAGE)]. Differences between GMI and laboratory HbA1c were assessed by the absolute value of the hemoglobin glycation index (HGI). Results: A total of 91 sensor data and corresponding laboratory HbA1c, as well as demographic and clinical characteristics were analyzed. GMI and HbA1c were 7.20 ± 0.67% and 7.52 ± 0.73%, respectively. The percentage of subjects with absolute HGI 0 to lower than 0.1% was 21%. GMI was significantly associated with laboratory HbA1c after basic adjustment (standardized β = 0.83, p Conclusions: This study validated the GMI formula using the iPro™2 sensor in adult patients with T1D. GV influenced the relationship between GMI and laboratory HbA1c. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|