Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome
| Autor: | Hima Makala, Kalishwaralal Kalimuthu, Young Sun Lee, Yong Seok Park, Yong J. Lee, Simon C. Watkins, Yong Tae Kwon, M. Haroon A. Choudry, David L. Bartlett |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Programmed cell death Physiology Clinical Biochemistry Apoptosis medicine.disease_cause Article Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor medicine Autophagy Ferroptosis Humans Bortezomib Endoplasmic reticulum Autophagosomes Cell Biology Glutathione Endoplasmic Reticulum Stress HCT116 Cells Cell biology Oxidative Stress 030104 developmental biology chemistry 030220 oncology & carcinogenesis Unfolded protein response Lipid Peroxidation Oxidation-Reduction Oxidative stress Heme Oxygenase-1 medicine.drug Signal Transduction |
| Zdroj: | J Cell Physiol |
| ISSN: | 1097-4652 |
| Popis: | Ferroptosis has been reported as a unique form of cell death. However, in recent years, researchers have increasingly challenged the uniqueness of ferroptosis compared to other types of cell death. In this study, we examined whether ferroptosis shares cell death pathways with other types of cell death, especially autophagy, via the autophagic process. Here, we observed that ferroptosis inducers (artesunate and erastin) and autophagy inducers (bortezomib and XIE62–1004) led to autophagosome formation via the endoplasmic reticulum (ER) stress response. Unlike XIE62–1004, artesunate, erastin, and bortezomib, which affect glutathione production or utilization, induced oxidative stress responses - an increase in the levels of heme oxygenase-1 and lipid peroxidation. Oxidative stress responses were attenuated by deletion of autophagy related gene-5 or treatment with autophagy inhibitors (bafilomycin and chloroquine). Our studies provide an overview of common death pathways - the ER stress response-associated autophagic process in ferroptosis and autophagy. We also highlight the role the glutathione redox system plays in the outcome of the autophagic process. |
| Databáze: | OpenAIRE |
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