Interhemispheric transfer of working memories
| Autor: | Mikael Lundqvist, Simon Kornblith, Scott L. Brincat, Earl K. Miller, Jacob A. Donoghue, Meredith Mahnke |
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| Přispěvatelé: | Picower Institute for Learning and Memory |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine genetic structures Working memory General Neuroscience Prefrontal Cortex Cognition Engram Macaca mulatta Functional Laterality Lateralization of brain function 03 medical and health sciences Memory Short-Term 030104 developmental biology 0302 clinical medicine Laterality Saccade Visual Perception Animals Directionality Female Prefrontal cortex Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Elsevier |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2021.01.016 |
| Popis: | Visual working memory (WM) storage is largely independent between the left and right visual hemifields/cerebral hemispheres, yet somehow WM feels seamless. We studied how WM is integrated across hemifields by recording neural activity bilaterally from lateral prefrontal cortex. An instructed saccade during the WM delay shifted the remembered location from one hemifield to the other. Before the shift, spike rates and oscillatory power showed clear signatures of memory laterality. After the shift, the lateralization inverted, consistent with transfer of the memory trace from one hemisphere to the other. Transferred traces initially used different neural ensembles from feedforward-induced ones, but they converged at the end of the delay. Around the time of transfer, synchrony between the two prefrontal hemispheres peaked in theta and beta frequencies, with a directionality consistent with memory trace transfer. This illustrates how dynamics between the two cortical hemispheres can stitch together WM traces across visual hemifields.Brincat et al. use bilateral recording to show working memories transferring between the right and left prefrontal cortex. Transferred memories engage different ensembles than feedforward-induced memory traces. Trace transfer is accompanied by directed interhemispheric theta/beta synchrony. NIMH (Grant R37MH087027) ONR (Grant MURI N00014-16-1-2832) NIGMS (Grant T32GM007753) |
| Databáze: | OpenAIRE |
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