Immunogenicity and cross-reactivity against Mycobacterium tuberculosis of proteoliposomes derived from Mycobacterium bovis BCG
| Autor: | María E. Sarmiento, Mohd Nor Norazmi, Sonsire Fernández, Yanely Tirado, José Luis Monereo Pérez, Fátima Reyes, Giselle Reyes, Armando Acosta, Reinier Borrero, Ramlah Kadir, Caridad Zayas, Alina Puig |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Tuberculosis Proteolipids Immunology Population Biology Cross Reactions Microbiology Mycobacterium tuberculosis Membrane Lipids Mice Antigen Bacterial Proteins Cell Wall medicine Animals education Mycobacterium bovis education.field_of_study Antigens Bacterial Mice Inbred BALB C Immunogenicity medicine.disease biology.organism_classification Virology Antibodies Bacterial Proceedings Immunoglobulin G biology.protein BCG Vaccine Antibody BCG vaccine |
| Zdroj: | BMC Immunology |
| ISSN: | 1471-2172 |
| Popis: | The only currently available vaccine against tuberculosis (TB) is Mycobacterium bovis Bacille Calmette-Guerin (BCG), which has inconsistent efficacy to protect against the disease in adults. M. tuberculosis (MTB) cell wall components have been implicated in the pathogenicity of TB and therefore have been a prime target for the identification and characterization of cell wall proteins with potential application in vaccine development. In this regard, proteoliposomes (PLs) derived from mycobacteria containing lipids and cell wall proteins could be potential vaccine candidates against TB. In the present study PLs derived from BCG were prepared. These homogeneous population of spherical microparticles was then immunized into Balb/c mice. Sera of immunized animals showed high IgG response and strong cross-reactivity against different MTB antigens.These results showed that BCG PLs could be potential vaccine candidates against TB. |
| Databáze: | OpenAIRE |
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