Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy
| Autor: | Mônica Almeida Falconi, Arthur C. Ouwehand, Celio Kenji Miyasaka, Kathia Hitomi Tsuboi, Marina Rachel Araújo, Nelson Adami Andreollo, Elisvânia Freitas dos Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Vitamin
Male Prebióticos medicine.medical_specialty medicine.medical_treatment Iron Hematocrit Gastroenterology Excretion chemistry.chemical_compound Eating Feces Random Allocation Gastrectomy Internal medicine medicine Ingestion Animals Mineral absorption Rats Wistar Glucans Gastrectomia Ratos Billroth II Analysis of Variance medicine.diagnostic_test Polydextrose business.industry Body Weight Anemia Surgery Diet Rats Prebiotics chemistry Intestinal Absorption business Ferro |
| Zdroj: | Acta Cirúrgica Brasileira v.25 n.6 2010 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 25, Issue: 6, Pages: 518-524, Published: DEC 2010 |
| Popis: | PURPOSE: To investigate whether polydextrose stimulates iron absorption in rats submitted to partial gastrectomy and sham operated. METHODS: The rats were submitted to partial gastrectomy (Billroth II) or laparotomy (sham-operated control), in groups of 20 and 20 each respectively. The animals were fed with a control diet (AIN-93M) without polydextrose or a diet containing polydextrose (50g/Kg of diet) for eight weeks. They were divided into four subgroups: sham-operated and Billroth II gastrectomy and with or without polydextrose. Two animals died during the experiment. All rats submitted to gastrectomy received B-12 vitamin (intramuscular) each two weeks. The hematocrit and hemoglobin concentration were measured at the start and on day 30 and 56 after the beginning of the experimental period. At the end of the study, the blood was collected for determination of serum iron concentration. RESULTS: The diet with polydextrose reduced the excretion of iron. Apparent iron absorption was higher in the polydextrose fed groups than in the control group. The haematocrit and haemoglobin concentration were lower after Billroth II gastrectomy rats fed the control diet as compared to the polydextrose diet groups. CONCLUSION: Polydextrose increase iron absorption and prevents postgastrectomy anemia. OBJETIVO: Investigar se a polidextrose estimula a absorção de ferro em ratos submetidos à gastrectomia parcial e sham operados. MÉTODOS: Os ratos foram submetidos à gastrectomia parcial (Billroth II) e à laparotomia (controle sham-operados) em grupos de 20 e 20 cada, respectivamente. Os animais foram alimentados com uma dieta controle (AIN-93M), sem polidextrose ou uma dieta contendo polidextrose (50g/kg de dieta) durante oito semanas. Foram divididos em quatro grupos: sham-operados e com gastrectomia BII e com ou sem polidextrose. Dois animais morreram durante o experimento. Todos os ratos com gastrectomia receberam vitamina B-12 (intramuscular) a cada duas semanas. O hematócrito e a hemoglobina foram dosados no início e nos dias 30 e 56 após o início do período experimental. No final do estudo, o sangue foi coletado para determinação da concentração de ferro sérico. RESULTADOS: A dieta com polidextrose reduziu a excreção de ferro e a absorção de ferro aparente foi maior nos grupos alimentados com polidextrose do que no grupo controle. As dosagens de hematócrito e hemoglobina foram menores em ratos com gastrectomia alimentados com a dieta controle em relação aos grupos de dieta com polidextrose. CONCLUSÃO: A polidextrose aumenta a absorção do ferro e previne a anemia pós-gastrectomia. |
| Databáze: | OpenAIRE |
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