Metabolic risks of hyperuricemia
Autor: | L. N. Dolgova, I. G. Krasivina, N. V. Dolgov, D. G. Lugovkina |
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Rok vydání: | 2019 |
Předmět: |
metabolic syndrome-associated cardiovascular diseases
medicine.medical_specialty hyperuricemia Type 2 diabetes allopurinol 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound gout 0302 clinical medicine Diabetes mellitus Internal medicine medicine Hyperuricemia 030203 arthritis & rheumatology febuxostat business.industry Type 2 Diabetes Mellitus General Medicine medicine.disease Gout chemistry diabetes mellitus Medicine Uric acid Metabolic syndrome business Kidney disease |
Zdroj: | Медицинский совет, Vol 0, Iss 18, Pp 76-84 (2019) |
ISSN: | 2658-5790 2079-701X |
DOI: | 10.21518/2079-701x-2019-18-76-84 |
Popis: | Hyperuricemia (HU), traditionally considered as an important risk factor and therapeutic target for patients with gout, currently draws attention of many researchers from the perspective of its contribution to the pathogenesis of metabolic syndrome and metabolic syndrome-associated diseases. The study aimed to determine the frequency of detection of HU and its conjugation with burden of metabolic comorbidities in outpatients. HU was detected in 253 (27.1%) of 933 people referred to the determination of the uric acid (UA) level. The investigators took into account the presence of established diagnosis of gout, cardiovascular system diseases associated with metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease (CKD) and urolithiasis, and nonalcoholic fatty liver disease. The study showed that patients with HU had four times higher metabolic comorbidity level than individuals with normal UA levels. Not only gout (6.25 times), but also urolithiasis with CKD (2.2 times) and cardiovascular disease (CVD) (1.9 times) were more common in people with elevated UA levels. Among patients with HU, women were 2.2 times more likely to have type 2 diabetes than men. Patients with type 2 diabetes and CVD, especially women, need to correct HU to reduce the risk of progression of metabolic disorders. The article presents a brief overview of modern drugs for the management of GU. |
Databáze: | OpenAIRE |
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