Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review
| Autor: | Josien G M Beijer, Rod Skinner, Cécile M. Ronckers, Lisanne C E Fioole, Renée L. Mulder, Jop C Teepen, Joke C. Korevaar, Eline van Dulmen-den Broeder, Elizabeth A.M. Feijen, Melissa M. Hudson, Jeanette F Winther, Nina Streefkerk, Wim J. E. Tissing, L. C. M. Kremer, Jaqueline J Loonen |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
severity grading childhood cancer survivors Childhood cancer MEDLINE Severity grading Outcome (game theory) Terminology Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] outcome definition 03 medical and health sciences 0302 clinical medicine Cancer Survivors Cost of Illness Survivorship curve Neoplasms Outcome Assessment Health Care Medicine Humans Intensive care medicine Adverse effect Child outcome assessment business.industry Long term morbidity Hematology long-term morbidity Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Morbidity business 030215 immunology |
| Zdroj: | Streefkerk, N, Fioole, L C E, Beijer, J G M, Feijen, E A M, Teepen, J C, Winther, J F, Ronckers, C M, Loonen, J J, van Dulmen-den Broeder, E, Skinner, R, Hudson, M M, Tissing, W J E, Korevaar, J C, Mulder, R L & Kremer, L C M 2020, ' Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors : A systematic review ', Pediatric Blood and Cancer, vol. 67, no. 11, e28611 . https://doi.org/10.1002/pbc.28611 Pediatric Blood & Cancer, 67 Pediatric Blood & Cancer, 67, 11 |
| ISSN: | 1545-5009 |
| Popis: | Item does not contain fulltext We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research. |
| Databáze: | OpenAIRE |
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