Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection
| Autor: | Carolyn M. Slupsky, David A. Mills, Michael L. Goodson, Amy M. Ehrlich, Britta E. Heiss, Jules A. Larke, Daniel J. Tancredi, Maria X. Maldonado-Gomez, Diana H. Taft, Helen E. Raybould |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Bifidobacterium pseudocatenulatum Oligosaccharides RC799-869 Gut flora bifidobacterium Inbred C57BL law.invention Probiotic Feces Mice fluids and secretions law 2.1 Biological and endogenous factors Colonization Aetiology Bifidobacterium Pediatric Gastrointestinal tract biology Gastroenterology Diseases of the digestive system. Gastroenterology Colitis Infectious Diseases Milk Breast Feeding Female Research Article Research Paper Human Microbiology (medical) Gut microbiota digestive system Microbiology Complementary and Integrative Health medicine Animals Humans Nutrition gut microbiota Catabolism biology.organism_classification medicine.disease colonization Gastrointestinal Microbiome Gastrointestinal Tract probiotics human milk oligosaccharides Digestive Diseases |
| Zdroj: | Gut microbes, vol 13, iss 1 Gut Microbes, Vol 13, Iss 1 (2021) Gut Microbes article-version (VoR) Version of Record |
| Popis: | Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments. Bifidobacterium species are naturally enriched in the gastrointestinal tract of breast-fed infants. Human milk oligosaccharides (HMOs) are associated with this enrichment. However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota. This study examined mice supplemented with the HMO 2ʹfucosyllactose (2ʹFL) together with a 2ʹFL-consuming strain, Bifidobacterium pseudocatenulatum MP80. 2ʹFL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants. This synergism impacted gut microbiota composition, activated anti-inflammatory pathways and protected against chemically-induced colitis. These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates. |
| Databáze: | OpenAIRE |
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