Measurement of Peripheral Vision Reaction Time Identifies White Matter Disruption in Patients with Mild Traumatic Brain Injury
| Autor: | Roderick W McColl, Christopher Paliotta, Jeremy F. Strain, Ramon Diaz-Arrastia, L. Christine Turtzo, William W. Lytton, Kyle B. Womack, Yosef Skolnick, Peter J. Bergold, Johnson S. Ho |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Visual perception Adolescent genetic structures Traumatic brain injury Vision Disorders Poison control 050105 experimental psychology Corpus Callosum White matter Young Adult 03 medical and health sciences 0302 clinical medicine Injury prevention Reaction Time medicine Humans Cognitive Dysfunction Glasgow Coma Scale 0501 psychology and cognitive sciences Brain Concussion 05 social sciences Neuropsychology Original Articles Middle Aged medicine.disease White Matter Diffusion Tensor Imaging medicine.anatomical_structure Anesthesia Peripheral vision Visual Perception Visual Field Tests Female Neurology (clinical) Psychology Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 34:1539-1545 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | This study examined whether peripheral vision reaction time (PVRT) in patients with mild traumatic brain injury (mTBI) correlated with white matter abnormalities in centroaxial structures and impairments in neuropsychological testing. Within 24 h after mTBI, crossed reaction times (CRT), uncrossed reaction times (URT), and crossed–uncrossed difference (CUD) were measured in 23 patients using a laptop computer that displayed visual stimuli predominantly to either the left or the right visual field of the retina. The CUD is a surrogate marker of the interhemispheric transfer time (ITT). Within 7 days after the injury, patients received a diffusion tensor-MRI (DTI) scan and a battery of neuropsychological tests. Nine uninjured control subjects received similar testing. Patients 18–50 years of age were included if they had a post-resuscitation Glasgow Coma Scale >13 and an injury mechanism compatible with mTBI. Healthy controls were either age- and gender-matched family members of the TBI patients or healthy volunteers. CUD deficits >2 standard deviations (SD) were seen in 40.9% of patients. The CUD of injured patients correlated with mean diffusivity (MD) (p |
| Databáze: | OpenAIRE |
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