The repertoire of glycan alterations and glycoproteins in human cancers
| Autor: | Beste Turanli, Kazim Yalcin Arga, Betul Karademir, Busra Aydin, Nurdan Kelesoglu, Ayşegul Caliskan Iscan, Gizem Gulfidan, Medi Kori, Can Erzik, Hande Beklen |
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| Přispěvatelé: | İstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü, Caliskan Iscan, Aysegul |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Glycan Glycosylation Genomics Computational biology Biology Sialylation Biochemistry Glycomics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polysaccharides Genetics medicine Humans Precision Medicine Molecular Biology Fucosylation Glycoproteins Cancer Glycan Alteration Tumor business.industry Fucosylation and Personalized Medicine medicine.disease Glycome carbohydrates (lipids) 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein Molecular Medicine Personalized medicine Glycoprotein business Biomarkers Biotechnology |
| Popis: | Cancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past, cancer studies heavily relied on genomics and transcriptomics with relatively little exploration of the glycan alterations and glycoprotein biomarkers among individuals and populations. Since glycosylation of proteins increases their structural complexity by several orders of magnitude, glycome studies resulted in highly dynamic biomarkers that can be evaluated for cancer diagnosis, prognosis, and therapy. Glycome not only integrates our genetic background with past and present environmental factors but also offers a promise of more efficient patient stratification compared with genetic variations. Therefore, studying glycans holds great potential for better diagnostic markers as well as developing more efficient treatment strategies in human cancers. While recent developments in glycomics and associated technologies now offer new possibilities to achieve a high-throughput profiling of glycan diversity, we aim to give an overview of the current status of glycan research and the potential applications of the glycans in the scope of the personalized medicine strategies for cancer. WOS:000628899900003 33404348 Q2 |
| Databáze: | OpenAIRE |
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