3 tera-basepairs as a fundamental limit for robust DNA replication
| Autor: | Timothy J. Newman, Luca Albergante, J. Julian Blow, M Al Mamun |
|---|---|
| Přispěvatelé: | Scottish Universities Life Sciences Alliance, Cancer Research UK, Wellcome Trust, National Institutes of Health (US), Mamun, Mohammed Al, Albergante, Luca, Blow, J. Julian, Newman, Thea, Mamun, Mohammed Al [0000-0003-3438-3997], Albergante, Luca [0000-0001-8151-6989], Blow, J. Julian [0000-0002-9524-5849], Newman, Thea [0000-0002-0332-337X] |
| Rok vydání: | 2020 |
| Předmět: |
DNA Replication
Cell division Biophysics Computational biology DNA replication Embryo development Genome Polyploidy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Structural Biology Gene duplication Humans Robustness Molecular Biology Genome size 030304 developmental biology 0303 health sciences Theoretical analysis Eukaryota Robustness (evolution) DNA Cell Biology Eutely Double fork stalls chemistry Tera 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1478-3975 1478-3967 |
| DOI: | 10.1088/1478-3975/ab8c2f |
| Popis: | 10 p.-2 tab. In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N_U ≈ 3×10^12 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota. MAM, LA and TJN acknowledge prior support from the Scottish Universities Life Sciences Alliance. JJB acknowledges support from Cancer Research UK (grant C303/A14301) and the Wellcome Trust (grant WT096598MA). TJN acknowledges prior support from the National Institutes of Health (Physical Sciences in Oncology Centers, U54 CA143682). |
| Databáze: | OpenAIRE |
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