Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor-mediated T cell hyporesponsiveness
| Autor: | Brian Gazzard, A. W. Rowbottom, D Sharpstone, M W Lepper |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Interleukin 2
CD3 Complex T-Lymphocytes medicine.medical_treatment T cell Immunology Cell Gene Expression Biology Lymphocyte Activation medicine Humans Immunology and Allergy IL-2 receptor Acquired Immunodeficiency Syndrome AIDS-Related Opportunistic Infections Cell growth NF-kappa B virus diseases Antibodies Monoclonal Virology medicine.anatomical_structure Cytokine Cell culture Cytomegalovirus Infections Leukocytes Mononuclear Interleukin-2 Original Article CD8 medicine.drug |
| Zdroj: | Clinical and Experimental Immunology. 111:559-563 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARYHIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor-mediated T cell hyporesponsiveness when compared with CD4-matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL-2. A typical increase in NFκB expression was observed following cross-linking of the CD3 receptor, but did not lead to increased CD25 cell surface expression or cell proliferation. The HCMV-induced non-responsiveness was not observed when cells were stimulated with phorbol esters. Lymphocytes cultured with media collected from cell cultures infected with HCMV showed a dose-dependent inhibition in the total T cell population even though cells staining dually for CD8/57 increased in number. The altered growth factor requirements of CD8/57+ cells may therefore account for their presence in AIDS and patients following bone marrow transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|