Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age
| Autor: | Mary A. Rutherford, Sean P. Fitzgibbon, Dafnis Batalle, A. David Edwards, Antonios Makropoulos, Ralica Dimitrova, Shona Falconer, Serena J. Counsell, Anthony N. Price, Judit Ciarrusta, Logan Z. J. Williams, Andrew Chew, Andreas Schuh, Daan Christiaens, Grainne M. McAlonan, Maximilian Pietsch, Emma C. Robinson, Jana Hutter, Daniel Rueckert, Joseph V. Hajnal, Jacques-Donald Tournier, Rui Pag Teixeira, Lucilio Cordero-Grande, Alexia Egloff, Emer Hughes, Jonathan O'Muircheartaigh, Olivia Carney |
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| Přispěvatelé: | Commission of the European Communities |
| Rok vydání: | 2021 |
| Předmět: |
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MOTION Cortical morphology Physiology HUMAN FETAL Pregnancy Cortex (anatomy) Medicine HETEROGENEITY FA fractional anisotropy 11 Medical and Health Sciences PMA postmenstrual age Cerebral Cortex PALM Permutation Analysis of Linear Models Radiology Nuclear Medicine & Medical Imaging Neonatal neuroimaging Brain HUMAN BRAIN Magnetic Resonance Imaging ddc 17 Psychology and Cognitive Sciences RF random forest medicine.anatomical_structure MSM multimodal surface matching Neurology Premature Birth Gestation Female dMRI diffusion MRI Life Sciences & Biomedicine Infant Premature RC321-571 MRI MAE mean absolute error ODI orientation dispersion index NODDI Neurite Orientation Dispersion and Density Imaging Cortical tissue Pregnancy Trimester Third Cognitive Neuroscience Gestational Age Neurosciences. Biological psychiatry. Neuropsychiatry Neuroimaging PWMLs punctate WM lessions SURFACE-AREA ORGANIZATION Article CEREBRAL-CORTEX THICKNESS Neonatal brain Humans WM white matter MD mean diffusivity Neurology & Neurosurgery Science & Technology BSID-III Bayley III Scales of Infant and Toddler Development TEA term-equivalent age Cortical development business.industry Term equivalent age Infant Newborn Neurosciences Postmenstrual Age Infant Preterm birth fICVF intracellular volume fraction SA surface area Brain Cortical Thickness medicine.disease dHCP developing Human Connectome Project MSE mean squared error Anisotropy Neurosciences & Neurology GPR gaussian process regression Heterogeneity business GA gestational age MRI magnetic resonance imaging MATTER |
| Zdroj: | NeuroImage, Vol 243, Iss, Pp 118488-(2021) Neuroimage |
| ISSN: | 1053-8119 |
| Popis: | INTRODUCTION: The dynamic nature and complexity of the cellular events that take place during the last trimester of pregnancy make the developing cortex particularly vulnerable to perturbations. Abrupt interruption to normal gestation can lead to significant deviations to many of these processes, resulting in atypical trajectory of cortical maturation in preterm birth survivors. METHODS: We sought to first map typical cortical micro- and macrostructure development using invivo MRI in a large sample of healthy term-born infants scanned after birth (n = 259). Then we offer a comprehensive characterization of the cortical consequences of preterm birth in 76 preterm infants scanned at term-equivalent age (37-44 weeks postmenstrual age). We describe the group-average atypicality, the heterogeneity across individual preterm infants, and relate individual deviations from normative development to age at birth and neurodevelopment at 18 months. RESULTS: In the term-born neonatal brain, we observed heterogeneous and regionally specific associations between age at scan and measures of cortical morphology and microstructure, including rapid surface expansion, greater cortical thickness, lower cortical anisotropy and higher neurite orientation dispersion. By term-equivalent age, preterm infants had on average increased cortical tissue water content and reduced neurite density index in the posterior parts of the cortex, and greater cortical thickness anteriorly compared to term-born infants. While individual preterm infants were more likely to show extreme deviations (over 3.1 standard deviations) from normative cortical maturation compared to term-born infants, these extreme deviations were highly variable and showed very little spatial overlap between individuals. Measures of regional cortical development were associated with age at birth, but not with neurodevelopment at 18 months. CONCLUSION: We showed that preterm birth alters cortical micro- and macrostructural maturation near the time of full-term birth. Deviations from normative development were highly variable between individual preterm infants. ispartof: NEUROIMAGE vol:243 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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