Nonhuman primates contribute unique understanding to anovulatory infertility in women
| Autor: | Deborah K. Bernett, David H. Abbott, Shu C. Foong, Daniel A. Dumesic |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Leptin
Primates Time Factors medicine.drug_class Reproductive Endocrinology Hypothalamus Physiology General Biochemistry Genetics and Molecular Biology Anovulation Gonadotropin-Releasing Hormone Stress Physiological medicine Animals Humans Ovarian Diseases Fetal programming Clinical treatment business.industry Pituitary gonadotropin General Medicine medicine.disease Nonhuman primate Hyperprolactinemia Disease Models Animal Animal Science and Zoology Female Gonadotropin business Infertility Female Hormone |
| Zdroj: | ILAR journal. 45(2) |
| ISSN: | 1084-2020 |
| Popis: | Anovulatory infertility affects a large proportion of reproductive-aged women. Major improvements in successful clinical treatment of this prevalent disorder in women's health have been made possible because of biomedical research employing nonhuman primates. Experiments on female rhesus monkeys were the first to demonstrate that the key hypothalamic neurotransmitter, gonadotropin-releasing hormone, involved in stimulating pituitary gonadotropin synthesis, storage, and release was bioactive only when released in approximately hourly bursts. This breakthrough in understanding gonadotropin regulation enabled identification of hypogonadotropic, apparently normogonadotropic, and hypergonadotropic forms of anovulatory infertility, and development of appropriate stimulatory or inhibitory gonadotropin therapies. Treatments to overcome anovulatory infertility represent one of the major advances in clinical reproductive endocrinology during the last 25 yr. The future promise of nonhuman primate models for human ovulatory dysfunction, however, may be based on an increased understanding of molecular and physiological mechanisms responsible for fetal programming of adult metabolic and reproductive defects and for obesity-related, hyperinsulinemic impairment of oocyte development. |
| Databáze: | OpenAIRE |
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