Low Plasma 25-Hydoxyvitamin D at Diagnosis Predicts Poor Outcomes in Patients with Bladder Cancer: A Prospective Cohort Study
| Autor: | Mohamed Kacem Ben Fradj, Mohamed Bassem Hammami, Yassine Nouira, Moncef Feki, Mokhtar Bibi, Amani Kallel |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty MEDLINE Medicine (miscellaneous) urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Internal medicine polycyclic compounds medicine Humans In patient Prospective Studies Vitamin D Prospective cohort study 030109 nutrition & dietetics Nutrition and Dietetics Bladder cancer business.industry Prognosis Vitamin D Deficiency medicine.disease Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Quality of Life business |
| Zdroj: | Nutrition and Cancer. 73:55-61 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635581.2020.1737150 |
| Popis: | This study aimed to investigate whether plasma 25-hydroxyvitamin D (25-OHD) at diagnosis predicts poor outcomes in patients with urothelial bladder cancer. A total of 177 patients with non-muscle-invasive bladder cancer (NMIBC) were prospectively followed up over a period extending beyond 6 years. Data on poor outcomes (ie., recurrence, progression, and mortality) were collected. Plasma 25-OHD was measured by immunoassay. Cutoff-Finder web application was used to determine the best 25-OHD cutoff point to predict a specific poor outcome. Cox-hazard models were applied to test how plasma 25-OHD affect patients outcome while adjusting for potential confounding factors. During the follow-up period, tumor recurrence and progression occurred in 40.7% and 14.1% of patients, respectively and 11.3% of patients died. Baseline 25-OHD was lower in patients who experienced poor outcome (12.2 ± 7.44 |
| Databáze: | OpenAIRE |
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