Obstructive sleep apnea, cardiovascular disease, and pulmonary hypertension
| Autor: | Jason M. Golbin, Virend K. Somers, Sean M. Caples |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult medicine.medical_specialty medicine.medical_treatment Hypertension Pulmonary Adult Obstructive Sleep Apnea Disease Risk Factors Internal medicine Positive airway pressure Medicine Humans Continuous positive airway pressure Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry Sleep apnea medicine.disease Pulmonary hypertension respiratory tract diseases Obstructive sleep apnea Cardiovascular Diseases Heart failure Cardiology Observational study business |
| Zdroj: | Proceedings of the American Thoracic Society. 5(2) |
| ISSN: | 1546-3222 |
| Popis: | With the growing epidemic of obesity in an aging population, obstructive sleep apnea (OSA) is increasingly encountered in clinical practice. Given the acute cardiopulmonary stressors consequent to repetitive upper airway collapse, as well as evidence for cardiovascular homeostatic dysregulation in subjects with sleep apnea, there is ample biologic plausibility that OSA imparts increased cardiovascular risk, independent of comorbid disease. Indeed, observational studies have suggested strong associations with multiple disorders, such as systemic hypertension, heart failure, cardiac arrhythmias, and pulmonary hypertension. Further data in the form of longitudinal cohort studies and randomized controlled trials are accruing to add to the body of evidence. This review examines pathophysiologic mechanisms and explores current concepts regarding the impact of OSA and its treatment on selected clinical disease states. |
| Databáze: | OpenAIRE |
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