Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers

Autor: Chris Bartlett, Kenny S. Crump, Liz Mittal, Shawn Hirsch, Annette C. Rohr, Deborah M. Proctor, Cynthia Van Landingham, Mina Suh, Raydel Valdes Salgado
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Chromium
Male
Lung Neoplasms
Epidemiology
Cumulative Exposure
Air Pollutants
Occupational
010501 environmental sciences
Toxicology
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Environmental health
Occupational Exposure
medicine
exposure-response modeling
Humans
Longitudinal Studies
Hexavalent chromium
Lung cancer
0105 earth and related environmental sciences
hexavalent chromium
Aged
Ohio
Proportional Hazards Models
Aged
80 and over
inhalation
Inhalation Exposure
business.industry
Proportional hazards model
Smoking
Public Health
Environmental and Occupational Health
risk assessment
Middle Aged
medicine.disease
030210 environmental & occupational health
Pollution
Confidence interval
Occupational Diseases
lung cancer
Standardized mortality ratio
chemistry
Chemical Industry
Cohort
Original Article
Female
business
Risk assessment
Zdroj: Journal of Exposure Science & Environmental Epidemiology
ISSN: 1559-064X
1559-0631
Popis: The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. The average length of follow-up was 34.4 years with 24,535 person-years at risk. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186; 95% confidence interval (CI) 145-228), for those hired before 1959, those with >30-year tenure, and those with cumulative exposure >1.41 mg/m(3)-years or highest monthly exposures >0.26 mg/m(3). Of the models assessed, the linear Cox model with unlagged cumulative exposure provided the best fit and was preferred. Smoking and age at hire were also significant predictors of lung cancer mortality. Adjusting for these variables, the occupational unit risk was 0.00166 (95% CI 0.000713-0.00349), and the environmental unit risk was 0.00832 (95% CI 0.00359-0.0174), which are 20% and 15% lower, respectively, than values developed in a previous study of this cohort.
Databáze: OpenAIRE
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