Beneficial Antiarrhythmic Effect of Beta-blockade in Patients with Dilated Cardiomyopathy
| Autor: | Toyofumi Wada, Kazuo Kihara, Yoshinori Koga, Hironori Toshima |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Cardiomyopathy Dilated Cardiac Complexes Premature medicine.medical_specialty Physiology Adrenergic beta-Antagonists Amiodarone Ventricular Function Left Tachycardia Internal medicine medicine Humans Potency In patient Beta (finance) Retrospective Studies medicine.diagnostic_test business.industry Arrhythmias Cardiac Dilated cardiomyopathy Middle Aged medicine.disease Myocardial Contraction Blockade Survival Rate Ambulatory Electrocardiography Ambulatory Cardiology Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Electrocardiography Follow-Up Studies medicine.drug |
| Zdroj: | Japanese Circulation Journal. 56:77-85 |
| ISSN: | 1347-4839 0047-1828 |
| Popis: | Antiarrhythmic effects of beta-blockade (BB) in patients with dilated cardiomyopathy were compared with those of various antiarrhythmic agents using ambulatory Holter monitoring. The BB therapy effectively suppressed ventricular extrasystoles (VEs) in 85% of patients, as evidenced by improvement in Lown's grade or a reduction in the number of the highest grade VEs greater than 50%. In contrast, conventional antiarrhythmic agents, except flecainaid and amiodarone, were poorly effective in suppressing VEs. BB therapy gradually increased left ventricular fractional shortening (16 +/- 6% to 22 +/- 12%) and improved 12-month survival rates as compared with those receiving conventional therapy (93 vs 69%). This antiarrhythmic potency seemed to be an additional therapeutic efficacy of BB in the management of patients with dilated cardiomyopathy, which frequently associated with serious VEs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|