Adrenalectomy, Corticosteroid replacement and their importance for drug-induced memory-enhancement in mice
| Autor: | A. Häusler, Cesare Mondadori, C. Persoz, Ajay S. Bhatnagar, R. Buser |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Mice Inbred Strains Endogeny Thymus Gland Adrenocorticotropic hormone Weight Gain Biochemistry Mice chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Memory Reference Values Corticosterone Internal medicine medicine Animals Aldosterone Molecular Biology Dose-Response Relationship Drug Adrenalectomy Piracetam Organ Size Cell Biology Blockade chemistry Molecular Medicine Corticosteroid medicine.drug |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 41:785-789 |
| ISSN: | 0960-0760 |
| Popis: | Adrenalectomy blocks the memory-improving effect of piracetam-like compounds in mice. If this blockade is due to the removal of endogenous corticosteroids, replacement therapy with exogenous corticosteroids should reinstate the effects on memory. The present experiments were designed to determine the appropriate replacement dose (concentration in the drinking fluid) for corticosterone and aldosterone, the main corticosteroids in mice. Based on the effects of corticosterone on thymus weight, replacement with 3 micrograms/ml corticosterone given in the drinking fluid (0.9% NaCl) for one week was found to be appropriate. The appropriate replacement dose for aldosterone was found by giving aldosterone to adrenalectomized (ADX) mice in the drinking fluid in combination with 3 micrograms/ml corticosterone. The combination of 3 micrograms/ml corticosterone + 30 ng/ml aldosterone resulted in a plasma ratio of corticosterone/aldosterone which most closely approximated the ratio seen in sham-ADX control animals. The physiologic adequacy of the corticosteroid replacement doses resulting from this study were clearly demonstrated in subsequent behavioral experiments where blockade of the memory-enhancing effects of piracetam by adrenalectomy were overcome by replacement with either 3 micrograms/ml corticosterone or 30 ng/ml aldosterone given in the drinking fluid. |
| Databáze: | OpenAIRE |
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