Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy
| Autor: | Ann A. Lazar, Adam A. Garsa, Sarah T. Arron, Melody J. Xu, Ivan H. El-Sayed, Sue S. Yom, Chase M. Heaton, Jonathan R. George, Alain Algazi, William R. Ryan, Patrick K. Ha |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Skin Neoplasms In-Transit Metastasis Metastasis Immunocompromised Host 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Cumulative incidence Neoplasm Metastasis Stage (cooking) Aged Neoplasm Staging Retrospective Studies Aged 80 and over Univariate analysis business.industry Proportional hazards model Mortality rate Age Factors Margins of Excision Cancer Middle Aged Prognosis medicine.disease Combined Modality Therapy Otorhinolaryngology 030220 oncology & carcinogenesis Multivariate Analysis Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Head & Neck. 40:1406-1414 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.25114 |
| Popis: | Background The purpose of this study was to assess changes resulting from the American Joint Committee on Cancer (AJCC) eighth edition for cutaneous squamous cell carcinoma (SCC) and evaluate pertinent excluded factors. Methods In 101 patients receiving surgery and postoperative radiation, recurrence and survival were estimated by cumulative incidence and Kaplan-Meier method. Time-to-event analysis was performed using Cox proportional hazards and Fine-Gray competing risks regression models. Results The 2-year locoregional recurrence, overall survival (OS), and cause-specific mortality rates were 25%, 72%, and 13%, respectively. The AJCC eighth edition upstaged T classification in 50% of patients and overall stage in 39%. In multivariate analysis, immunosuppression and in-transit metastasis were associated with locoregional recurrence. Older age and in-transit metastasis were associated with worse OS. In univariate analysis (limited by number of events), cause-specific mortality was associated with positive margin, in-transit metastasis, and the seventh edition dichotomized T classification and overall stage. Conclusion In-transit metastasis was significantly associated with locoregional recurrence, OS, and cause-specific mortality. Efforts should be made to define in-transit metastasis in the staging system. |
| Databáze: | OpenAIRE |
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