Mefloquine (WR 142,490) in the Treatment of Human Malaria
| Autor: | CJ Canfield, R. L. Williams, PE Carson, R. E. Desjardins, H Frischer, KH Rieckmann, CM Trenholme |
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| Rok vydání: | 1975 |
| Předmět: |
Drug
media_common.quotation_subject Plasmodium falciparum Drug Resistance Drug resistance Parasitemia Pharmacology Antimalarials Piperidines Chloroquine parasitic diseases Humans Medicine media_common Clinical Trials as Topic Multidisciplinary biology business.industry Mefloquine medicine.disease biology.organism_classification Mefloquine Hydrochloride Malaria Mutation Quinolines business medicine.drug |
| Zdroj: | Science. 190:792-794 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1105787 |
| Popis: | Mefloquine hydrochloride, a new 4-quinolinemethanol, was administered as a single oral dose to 47 volunteers infected with malaria. Treatment resulted in rapid clearence of fever and parasitemia. No recrudescence of parasites was observed after treatment of chloroquine-sensitive infections of Plasmodium falciparum. More significantly, in nonimmune persons with chloroquine-resistant infections, 1 gram of mefloquine cured 10 of 12 patients and 1.5 grams cured all 8 patients who received this dose of the drug. The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria. |
| Databáze: | OpenAIRE |
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