Effects of hetastarch and mannitol on prolonging survival in stable hypothermia in rats
| Autor: | Lawrence C.H. Wang, J. Westly, Tze-Fun Lee |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Physiology Plasma Substitutes Hypothermia Sodium Chloride Hematocrit Microcirculation Hydroxyethyl Starch Derivatives Rats Sprague-Dawley Erythrocyte Deformability Physiology (medical) medicine Animals Mannitol Hetastarch Blood Volume medicine.diagnostic_test business.industry Osmolar Concentration Diuretics Osmotic Survival Analysis Rats Plasma osmolality Red blood cell medicine.anatomical_structure Anesthesia Volume expander medicine.symptom business medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 278:R1040-R1047 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.2000.278.4.r1040 |
| Popis: | In rats, prolonged stable hypothermia (∼24 h at body temperature of 19°C) is characterized by a time-dependent increase in hematocrit, plasma osmolality, and red blood cell fragility and a decrease in plasma volume. These changes impede tissue microcirculation and could limit survival. As a countermeasure, we used plasma volume expanders of both long (hetastarch)- and short-lasting (mannitol) characteristics to improve microcirculation and hopefully hypothermia survival. Infusion of 6% hetastarch at hour 3 in hypothermia significantly ( P < 0.05) enhanced survival over saline control (33.5 vs. 23.8 h); a significant delay in the increases of hematocrit and cell fragility was also observed compared with those in saline controls. Treating the animal with 6% hetastarch at hour 20 during hypothermia caused a similar but less-effective improvement in survival. In contrast, treating the rats with 6% mannitol at hour 3 or 20 during hypothermia failed to enhance survival over saline control, although transient improvement in plasma volume was observed. Our results indicate that by using a long-lasting volume expander, which tends to better maintain plasma volume and rheological parameters governing microcirculation than does saline or a short-lasting volume expander, hypothermia survival can be significantly improved. |
| Databáze: | OpenAIRE |
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